![]() In patients taking theophylline, adverse effects might be noticed when a rutaecarpine-containing herbal preparation is used concomitantly. These results demonstrated that rutaecarpine treatment elevated CYP1A2 catalytic activity and theophylline excretion in rats. Pre-treatment of rats with 50 mg kg(-1) rutaecarpine caused a 3-fold increase in theophylline clearance and a 70%, 68% and 68% decrease in the area under the concentration-time curve (AUC), mean residence time (MRT) and half-life, respectively. Rutaecarpine pre-treatment increased the clearance of theophylline in a dose-dependent manner. Pharmacokinetic parameters of theophylline were determined using a microdialysis sampling method. In the lungs, EROD activity was elevated from an undetectable to a detectable level by rutaecarpine. In the kidney, rutaecarpine treatment caused a 3-fold increase in EROD activity. Oral treatment of Sprague-Dawley rats with 50 mg kg(-1) rutaecarpine for three days through a gastrogavage caused a 4- and 3-fold increase in liver microsomal 7-ethoxyresorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation activity, respectively. Evodia rutaecarpaex-tract and the herbal preparation Wu-Chu-Yu-Tang actas selective and potent inducers. To evaluate the pharmacokinetic interaction of theophylline with rutaecarpine, the effects of rutaecarpine on CYP1A2 activity and theophylline pharmacokinetics were investigated. Manydrugsimpactcaffeineclearance and half-life. The cytochrome P450 (CYP) 1A2 substrate, theophylline, is an important therapeutic agent for the treatment of asthma, but has a narrow therapeutic index. However, it is manufactured in a facility where whey protein is processed.Rutaecarpine is a main active alkaloid present in the medicinal herb, Evodia rutaecarpa. This product does not contain any ingredients of animal origin. Natural Flavor, Fruit & Vegetable Juice Powder (Color), DL-Malic Acid, Sucralose, Calcium Silicate, Silicon Dioxide, Potassium Chloride. ![]() Niacinamide, D-Calcium Pantothenate, Pyridoxine HCl, Riboflavin, Thiamine Mononitrate, Vitamin B12 Vitamin C (Ascorbic Acid), L-Glutamine, Inulin Fiber Taurine, L-Tyrosine, Caffeine Anhydrous, Guarana Seed Extract (50% caffeine), Green Coffee Bean Extract (50% Chlorogenic Acid), Huperzia Serrata Whole Herb Extract (Huperzine A) Nootropic Focus Cognitive Boosters (1018 mg) Hardcore Beta 3 Thermogenic Matrix (315.01 mg)Ĭonjugated Linoleic Acid (CLA), Bitter Orange Fruit Extract Powder (30% Synephrine Advantra Z), Raspberry Ketones (From Raspberry Fruit Extract), Evodiamine Fruit Powder (Evodia rutaecarpa), Chromium Picolinate If you are unsure of your caffeine sensitivity, start with 1/4 to 1/2 scoop taken before mid-day.Īcetyl L-Carnitine HCl, Glycine Propionyl-L-Carnitine Hydrochloride (GPLC GlycoCarn) Alternatively, take first thing in the morning. Mix 1 Scoop (4.9g) into 300ml cold water and take 15 minutes before exercise. With the addition of pure caffeine anhydrous, as well as naturally sourced caffeine from Guarana seed and Green Coffee Bean, EHP Labs Oxyshred Hardcore is a thermogenic energy booster you can't miss. This means carnitine levels are sustained over a longer period of time. They have added GPLC, which is another form of carnitine with a different half life to Acetyl L-Carnitine. Therefore, antiplatelet drugs significantly reduce the risk of severe CVDs. ![]() So the trade off is less fat and more energy. The role of activated platelets in acute and chronic cardiovascular diseases (CVDs) is well established. Carnitine help to move fatty acids into the mitochondria, where they are burned up for energy. This product can also be used for maintenance or as a solid pre-workout energy enhancer.Īcetyl L-Carnitine is one of the most popular nutrients for any weight loss program. It's also perfect for those times of increased training intensity or when you are ready to let those extra kilograms fall away to reveal a slimmer version of yourself. This is one of the reasons why EHP Labs have introduced Oxyshred Hardcore. Whether it takes half a tub or 6 tubs, we all know what it's like when a pre-workout or thermogenic enhancer loses its "kick". If you've been taking the original Oxyshred for a while and aren't quite getting the kick you used to, then you're ready for EHP Labs Oxyshred Hardcore. With an enhanced ingredient profile, this is a product you can count on to kick-start thermogenesis and keep your energy levels optimised. Oxyshred Hardcore delivers more of what we loved about the Original Oxyshred. ![]()
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